Role Summary

The Vice President, Medical Affairs will provide enterprise-level leadership across Lexeo’s gene therapy program. Reporting to the Chief Medical Officer, this role will set the strategic direction for Medical Affairs, overseeing scientific communications, congress strategy, external expert engagement, medical information, medical evidence generation and medical education. This individual will serve as a senior cross-functional leader and strategic partner to Clinical Development, Regulatory, and Patient Advocacy teams.

In this role, they will shape and scale the Medical Affairs function, build organizational capabilities, and drive external scientific leadership in support of Lexeo’s development and future commercialization objectives. The ideal candidate is a strategic, hands-on leader who thrives in a dynamic, high-growth environment and can influence across the organization and external stakeholders.

### Primary Responsibilities

Define and lead the global Medical Affairs strategy across Lexeo’s portfolio, ensuring alignment with development milestones and business objectives

Build, mentor, and lead a high-performing Medical Affairs organization, including external partners and future in-house team members

Own scientific communications strategy, including publications planning, congress strategy, medical education, and dissemination of clinical and disease-state insights

Establish and oversee external engagement strategy with key opinion leaders, investigators, medical societies, and patient advocacy organizations

Serve as the senior Medical Affairs representative in cross-functional governance, partnering with Clinical Development, Regulatory, Market Access, and Patient Advocacy leaders

Guide medical input into clinical development plans, patient identification strategies, launch readiness planning, and evidence-generation priorities

Oversee medical review processes and ensure high-quality, compliant externally facing scientific content and response materials

Lead advisory board strategy and execution, translating stakeholder insights into actionable plans for development and commercialization

Represent Lexeo externally at major scientific meetings, investigator forums, and executive-level partner interactions

Drive the development of onboarding, scientific training, and internal medical education initiatives to elevate organizational disease-area expertise

Lead medical evidence generation and align the same with company objectives

### Required Skills and Qualifications

Advanced degree in life sciences, medicine, or a related field required (MD, PharmD, PhD preferred) with 10+ years of industry experience

Significant Medical Affairs leadership experience in biotechnology or pharmaceuticals, with demonstrated progression in scope and responsibility

Deep expertise in scientific communications, external expert engagement, medical strategy, and cross-functional collaboration

Experience building or scaling Medical Affairs capabilities in a growth-stage organization, especially on transitioning from clinical stage to commercialization, is strongly preferred

Strong executive presence with excellent written and verbal communication skills and the ability to influence senior internal and external stakeholders

Ability to operate strategically while remaining hands-on in a fast-paced, evolving environment

Experience with real world datasets and studies

A working knowledge of how to incorporate artificial intelligence and machine learning principles into medical affairs

About Lexeo

Lexeo Therapeutics is a clinical-stage genetic medicine company headquartered in New York City, pioneering cardiac genetic medicine candidates to treat the root causes of inherited cardiovascular diseases. Our lead program, LX2006, targets cardiomyopathy associated with Friedreich’s Ataxia and anchors a broader pipeline addressing genetically defined conditions such as hypertrophic and arrhythmogenic cardiomyopathies. Backed by a strong financial foundation, Lexeo is positioned to translate groundbreaking science into durable clinical impact.

Our work culture is a hybrid model with 2 days/week in the New York City office and 3 days working from home.

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.

Vice President, Medical Affairs

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