Definium Therapeutics is a late-stage clinical biopharmaceutical company and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale.

Our lead product candidate, lysergide tartrate (our proprietary orally disintegrating tablet form of lysergide (LSD) D-tartrate), represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder. Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges.

Guided by the recognition that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to address the underlying causes of psychiatric and neurological disorders. By turning evidence into impact, Definium aims to change the trajectory of today’s mental health care crisis and enable a healthier future. Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX.

Together we are moving psychiatry forward—beyond better, into a boundless future. Join us!

Reporting to the Sr. Director of Information Technology, the End-User Computing (EUC) Engineer will be responsible for providing primary operational support for end-user hardware and software for a fully remote and geographically distributed company with a growing physical presence in Raleigh/Durham, San Diego and Philadelphia. The prospective candidate will provide level 1 and 2 support for the enterprise and collaborate with senior members of IT on resolution of next-level support issues. The candidate will drive and participate in design, architecture, engineering, implementation, and operations of Definium global SaaS IT and business application portfolio to establish and maintain core operational, compliance, security, privacy, and other KPIs and standards. He/she will have a passion for problem solving, thrives in a diverse global organization, provides an excellent end-user experience, explores innovative technologies, and is driven to seek continuous improvement.

Responsibilities:

Provide operational support for remote staff. This will include hardware and software issues
Create, update, triage, and close support tickets in the Definium ITSM to ensure a thorough documentation of requests and incidents, end-user communication, root cause analysis and resolution
IT lead for all new and departing employee responsibilities. Ensure compliance with all on-boarding and off-boarding policies and procedures
Coordinate the hardware lifecycle for remote employees from procurement, configuration, collection, and retirement
Provide primary/secondary system administration to IT systems
Work closely with IT MSPs and professional service providers
Assist in identifying, evaluating, justifying, and deploying, new products, technologies, systems, services, and workflows
Independently perform actions under departmental change control procedures with minimal oversight or assistance
Ensure compliance for technology projects and processes including Sarbanes Oxley (SOX), 21 CFR Part 11, cGxP, and GDPR
Author and review standard operating procedures and knowledge-based articles for the maintenance and operation of software applications
Ensure that best practices for the service and support of technology products are documented and followed
Stay up to date on industry trends and best practices

Qualifications:

Minimum bachelor’s degree or equivalent work experience
2+ years of Tier I operational support experience, preferably within a regulated life sciences environment that has a remote or hybrid workforce
2+ years supporting macOS and Windows laptops via MDM
2+ years supporting Identity platforms [OKTA or Entra/AzureAD]
2+ years supporting SaaS applications
Experience administering Co-Pilot, M365, SharePoint, Powershell, Cisco Umbrella, CrowdStrike, CheckPoint, M365, Slack, Zoom, DocuSign, FreshService, Intune, Kandji, Apple Business Manager, Adobe, and OKTA
Strong verbal and written communication skills
Excellent vendor management and negotiation skills
Strong remote triaging skills
Strong experience managing SharePoint sites and M365 permissions
SOX and/or 21 CFR Part 11 experience
Experience supporting multiple operating systems (Windows 11, iOS, and MacOS)
ITIL certification preferred

The starting base pay range for this position is $100,932.00 - 123,380.00. Compensation will be determined based on several factors including, but not limited to, skill set, years of experience, and the employee’s geographic location.

Employees in this role may be entitled to additional compensation, including bonus and equity. Benefits information is listed on our Jobs Page. The Company provides competitive benefits to employees including:

End User Computing Engineer

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Definium Therapeutics