Senior Research Scientist – Pharmacokinetics

Each of us cares about someone who will need medicines. That’s why our vision is to repeatedly beat the odds to deliver breakthrough medicines to patients that need them. We pursue truth and scientific rigour and have the courage to work at the edge of the unknown.

We are seeking a highly motivated Senior Research Scientist with a strong understanding of pharmacokinetics and bioanalytical methods to join our multidisciplinary Pharmacokinetics (PK) team. Based in Vancouver, you will be instrumental in bridging the gap between discovery and the clinic, specifically driving the bioanalytical and ADME strategies and execution with a focus on antibody drug conjugate (ADC) programs. In this role, you will collaborate with cross-functional teams, including non-clinical safety, modeling and simulations, protein sciences, and the clinical and regulatory teams, to support the progression of our projects from discovery to development.

How you might spend your days:

• Leading external activities for establishing, qualifying, and validating ligand-binding assays and LC-MS/MS methods to support the preclinical and clinical development of novel ADC therapeutics, including measurement of drug concentration and anti-drug antibodies
• Characterizing the ADME profile for ADC candidates, including assessing the drug-drug interaction (DDI) potential of released small molecule payloads
• Leading the analysis, interpretation, and reporting of PK/ADME data to support regulatory filings (IND/CTA), including authoring and reviewing high-quality study reports, briefing packages, and regulatory documents
• Collaborating with cross-functional project teams where you'll represent the PK function, and interacting externally with CROs or consultants
• Training and mentoring scientists

We’d love to hear from you if:

• You are an expert in the design, development, and phase-appropriate qualification/validation of LC/MS-MS bioanalytical assays to support preclinical and clinical development
• You have demonstrated expertise in authoring sections of regulatory submissions
• You are comfortable with non-compartmental data analysis (WinNonlin), and have a good understanding of PK parameters
• You have 8+ years of relevant industry experience in addition to a PhD in Biology, Pharmacology, or related discipline; candidates with a MSc and 10+ years of industry experience will also be considered
• You are genuinely curious and energized by working with teammates to discuss innovative ideas in a highly collaborative and fast paced environment
• You excel in documentation and organizational skills and clearly communicate scientific and technical concepts both verbally and in writing
• You have direct experience with PK profiling of ADCs (considered a strong asset)

What we offer:

AbCellera’s hiring range for this role is CAD $112,000 - $132,000 annually, commensurate with your education and job-related knowledge, skills, and experience. In addition to base salary, we offer equity, annual bonus dependent on team and company performance, and a 6% (non-match) RRSP contribution.

You will have a CAD $1,500 annual Active Lifestyle Allowance, annual vacation, opportunity for flexible work arrangements, professional development opportunities, and comprehensive health benefits. Scientific and technical mentorship is a priority. And you’ll find a strong sense of community and connections across AbCellera through our work, clubs, and socials.

About AbCellera:

Creating medicines is the most important work we can do.

We are a clinical-stage biotechnology company focused on discovering and developing antibody-based medicines in the areas of endocrinology, women’s health, immunology, and oncology. We have built a platform for advancing antibody drug programs from target to clinic, and we are using it to build our internal pipeline.

Today, our pipeline includes two drug candidates in clinical development, two preclinical development candidates (DCs) in Investigational New Drug (IND)-enabling activities, and more than 20 active discovery programs across multiple modalities and indications.

We believe that when tenacious people share a vision and work together, they can truly have a positive impact. That’s why we hire for character and intelligence, not just for CVs or experience.

We look for people with drive and energy. People we trust. People who need to know their days are being well spent. That their work really matters. In the end, our success will be measured by the impact of our medicines.

To apply: