Principal Signal Processing / Algorithm Engineer
Posted about 2 months ago
Location: San Diego, CA | Full-Time | Salary: $260,000 – $270,000
Position Overview
We are building a high-throughput analysis system for noisy, information-rich measurement data. The work sits at the boundary of signal processing, statistical estimation, physical-system modeling, and production software. The core challenge is turning an ambiguous real-world signal into a calibrated algorithm that can be trusted under operational constraints.
This role owns algorithmic formulation and delivery. You will identify the right model for the signal, define the measurements that matter, build the algorithmic path from prototype to production, and work with partner teams when the data shows that the physical system or measurement process needs to change.
The strongest fit is a hands-on principal engineer who can sit with an imperfect signal, derive the right question, defend the math, write production-intent code, and explain the tradeoff in plain language to people outside their specialty.
Roles and Responsibilities
Formulate and ship algorithms for noisy measurement data, including estimation, detection, calibration, confidence modeling, drift analysis, and systematic-error reduction
Build modeling and analysis frameworks that explain current performance, identify the factor limiting data quality, and prioritize the next experiment or engineering change
Use simulation and controlled datasets to make algorithm work falsifiable: isolate failure modes, bound achievable performance, and separate model error from measurement error
Work directly with hardware, measurement, and production-engineering partners on what to measure, what to change, and how to tell whether a change improved the system
Write production-intent code with clear interfaces, deterministic behavior, and tests grounded in measured or simulated truth
Translate algorithmic insight into product and system-design decisions without turning every discussion into a research project
What We're Looking For (Must-Haves)
First-principles problem formulation. Given a noisy, partly characterized signal and an incomplete goal, you can derive the right question before reaching for tools. You can defend an SNR estimate, likelihood model, error budget, or bias/variance tradeoff from the ground up.
Shipped algorithmic ownership. You have personally taken an algorithm in signal processing, communications, radar, computational sensing, imaging, controls, physical-layer systems, or a comparable domain from problem statement to a deployed system other people depend on.
Production toolchain fluency. You are strong in Python for analysis and prototyping, and you can write production-intent Rust or modern C++ where correctness, speed, memory layout, and maintainability matter. MATLAB-only experience is not enough for this role.
Cross-disciplinary collaboration. You have shaped measurement, hardware, or physical-system decisions using algorithmic evidence, not just consumed data handed to you by another team.
Curiosity about the source of the data. You want to understand what the system actually measured, how the data was produced, and which assumptions are safe enough to encode.
Education
MS or PhD in EE, CS, Physics, Applied Math, Statistics, or related field or equivalent demonstrated work
MS + 14 years, or PhD + 10 years, in DSP, image analysis, communications, physical-layer algorithms, computational imaging, or comparable. What matters is demonstrated depth and shipped ownership
Strongly Preferred
Rust at shipping depth for performance-critical algorithm or numerical components
Communication-theory or estimation-theory tools applied outside their original domain: maximum-likelihood detection, decision feedback, adaptive filtering, channel modeling, state estimation, or related methods
GPU-accelerated algorithm work in a real performance regime, especially CUDA or comparable accelerator programming
Experience with simulation-driven algorithm development where the simulator and algorithm improve together
ML used as one tool inside a broader estimation or signal-processing framework, with clear understanding of where it helps and where it hides failure modes
Public or shareable evidence of depth: papers, patents, open source, technical talks, postmortems, or a concrete shipped system you can discuss
Nice to Have
Physical measurement systems with non-trivial analysis pipelines
Calibration and confidence / quality modeling on production outputs
Custom FFI or systems-language boundaries for performance-critical numerical code
Experience helping non-algorithm teams use diagnostics without oversimplifying the underlying model
We are an equal opportunity employer. We thrive on diversity and collaboration.
Foresite Labs creates companies at the intersection of AI/machine learning and science. We believe AI, generative AI, and data science—when applied with scientific rigor—can accelerate discovery and drive innovations that benefit humanity. We provide the foundation for bold ideas to take shape and accelerate, shaping a better future for all. We offer competitive salaries, excellent benefits, and a flexible work environment where employees learn from top thinkers across multiple disciplines. With headquarters in San Francisco and Boston, we’re building a culture where scientific rigor meets entrepreneurial ambition. Foresite Labs Values Truth over progression: We follow the science, pursuing ideas that are grounded in data and abandoning them when not supported by the evidence. Take good risks: Our culture values informed risk-taking: good decisions are celebrated even when they result in bad outcomes. Everyone feels safe to contribute ideas and to learn from failure. Single accountable person: The project team lead is accountable for all decisions and for maintaining transparency and information flow within the team; we trust the project teams. The Review Committee unlocks capital and sets directions. Simplicity and Focus: “Companies die from indigestion, not starvation” (Bill Hewlett) We will focus on a few ideas aggressively and minimize all other distractions. Everyone will have a few key goals that have measurable outcomes. Respect and Community: Our employees are our greatest asset; everyone invests in creating an environment of collaboration and respect. We support their careers and career development whether they stay, go to a Labs company, or end up somewhere else.
Key team members

Alex Aravanis MD PhD

Damien Soghoian

Christopher Baldwin

Kylie Reynolds
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