Ready to redefine what's possible in molecular diagnostics?

Join a team of brilliant, passionate innovators who wake up every day determined to transform healthcare. At BillionToOne, we've built something extraordinary—a culture where transparency fuels trust, collaboration drives breakthroughs, and every voice matters in our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we strive to build products that are 10x better than anything that exists today. Our people are our greatest asset: talented scientists, engineers, sales professionals, and visionaries united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion—every innovation you contribute helps remove fear of unknown from some of life's most critical medical moments. If you're driven by purpose, energized by innovation, and ready to help build the future of precision medicine, this is where you belong.

BillionToOne is seeking an experienced Associate Director/Director AI Engineer to join our Enterprise Architecture / Data Science organization and lead the design, execution, and scale-up of AI initiatives across our enterprise. This hybrid role blends deep technical expertise in Generative AI with program management excellence, enabling enterprise-level adoption and transformation.

Reporting to the VP of Data Science/IS,IT, you’ll partner closely with executive leadership and business unit leaders to drive the enterprise-wide GenAI strategy, deliver measurable value, and unlock operational efficiencies across Commercial and SG&A teams. You will serve as a thought leader and architect of GenAI-enabled innovation at BillionToOne. This is a hybrid (onsite 3-4 days/week) position and reports to the VP, IS/IT.

Responsibilities:

AI Strategy & Leadership
- Develop and lead the company-wide strategy for Generative AI adoption.
- Serve as a consultative partner to executive leadership and business units, identifying and prioritizing high-impact AI opportunities.
- Design end-to-end AI solutions that integrate with existing enterprise architecture and comply with IT security, privacy, and governance standards.
- Act as a thought leader, internally and externally, on practical GenAI applications, AI ethics, and industry best practices.
AI Architecture & Delivery
- Conduct user interviews and define technical and functional requirements.
- Conduct technical assessments of vendor solutions and manage relationships with AI technology partners.
- Evaluate and implement platforms such as Azure AI, AWS SageMaker, and Google Vertex AI.
- Establish and enforce MLOps practices for model deployment, monitoring, and version control.
- Design APIs and microservices for real-time AI inference and integration across business workflows.
- End-to-end feasibility to delivery, including: leading proof-of-concepts, validating ROI, development, integration and testing.
- Mentor other AI developers on best practices, frameworks, and architectural patterns.
- Knowledge of data engineering concepts and tools (SQL, ETL/ELT, data warehousing).
Program Management & Execution
- Lead proof-of-concept development to validate technical feasibility and business value.
- Drive continuous improvement in AI delivery processes and methodologies.
- Manage a portfolio of 3–5 concurrent AI projects from concept to deployment.
- Own delivery timelines, budgets, milestones, and success metrics.
- Facilitate stage-gate reviews with clear go/no-go criteria.
- Partner with IT, Data Science, Legal, and security teams to ensure governance and compliance.
Business Enablement & Change Management
- Partner with business leaders in sales, marketing, finance, and operations to identify high-value AI opportunities.
- Translate business needs into AI solutions and demonstrate tangible ROI.
- Create detailed technical specifications, reference architectures, and implementation roadmaps for AI initiatives.
- Coordinate cross-functional teams including data scientists, business analysts, and IT infrastructure.
- Facilitate design thinking workshops to rapidly prototype AI solutions and drive stakeholder engagement.
- Collaborate with operational leaders and embedded analysts to ensure AI integration into daily workflows.
- Serve as a thought leader, internally and externally, advocating and educating on the potential and practical application of Generative AI.
- Track adoption and effectiveness of AI solutions and refine as needed.Help shape the enterprise-wide AI strategy across employee productivity, commercial and lab operation teams.

Qualifications

Bachelor's degree in Computer Science, Engineering, or related technical field (Master's preferred)
7+ years of experience in solution architecture, with at least 3 years focused on AI/ML implementations
Proven track record of delivering enterprise-scale technology solutions from concept to production with commercial stakeholders
Hands-on experience with data technologies
Expertise in at least one programming language (Python preferred, Java/C# acceptable)
Experience with API design, microservices architecture, and enterprise integration patterns
Excellent communication skills with ability to explain complex technical concepts to business audiences
Strong analytical and problem-solving abilities with a data-driven approach
Ability to influence and build consensus across technical and business stakeholders
Strategic thinking with the ability to connect technical capabilities to business outcomes
Self-motivated with ability to work independently and manage multiple priorities

Nice-To-Haves:

Experience in SG&A functions (sales operations, marketing analytics, medical affairs)
Knowledge of specific AI use cases: predictive analytics, NLP, computer vision, process automation
Experience with business intelligence tools and data visualization
Experience in mid-size companies (300-1000 employees) undergoing digital transformation

Benefits And Perks:

Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
Open, transparent culture that includes weekly Town Hall meetings
The ability to indirectly or directly change the lives of hundreds of thousands patients
Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
Free UNITY Complete NIPT testing for employees & spouses
Supplemental fertility benefits coverage
Retirement savings program including a 4% Company match
Increase paid time off with increased tenure
Latest and greatest hardware (laptop, lab equipment, facilities)
Free daily on-site lunches provided from top eateries
A variety of perks on campus (state of the art gym, restaurant)
Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.).

For this position, we offer a total compensation package of up to $437,370 per year, including a base pay range of $234,090 - $260,100 per year.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

For more information about how we protect your information, we encourage you to review our Privacy Policy.

About BillionToOne

BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA—a breakthrough that's already transformed the lives of over half a million patients worldwide.

Our Impact: We've pioneered game-changing diagnostic solutions that are redefining industry standards. Unity Complete™ stands as the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. In oncology, our Northstar® liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.

Our Growth: From $0 to $125 million in Annual Recurring Revenue in just four years. We've raised close to $400 million in funding, including a $130 million Series D round in June 2024, achieving a valuation of over $1 billion. This backing comes from world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

Our Recognition: Forbes recently named us one of America's Best Startup Employers for 2025, and we were awarded Great Place to Work certification in 2024—with an incredible 100% of our people reporting they are willing to give extra to get the job done. These honors recognize not just our innovation but the exceptional culture we've cultivated—one that remains authentically collaborative and transparent even as we've scaled.

Our Future: Headquartered in Menlo Park with facilities in Union City, California, we're continuing to push the boundaries of what's possible in molecular diagnostics. Recent clinical outcomes data for Unity Fetal Risk Screen and new advances in cancer diagnostics prove we're just getting started.

At BillionToOne, you'll join a diverse team of passionate innovators who believe that the best science happens when brilliant minds collaborate openly, think boldly, and never lose sight of the patients whose lives depend on our work.

Ready to help us change the world, one diagnosis at a time?

Learn more at www.billiontoone.com

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