Associate Scientific Director, Medical Affairs – Real World Evidence (RWE) Generation

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.  

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking Associate Scientific Director, Medical Affairs – Real World Evidence (RWE) Generation as part of the Medical Affairs team based Remotely. 

Role Overview

The Associate Scientific Director, US Medical Affairs, will supervise the Real World Evidence (RWE) strategy and evidence generation initiatives at Legend Biotech. This role is responsible for the design, execution, and dissemination of RWE studies and related research activities to support medical adoption, product differentiation, and lifecycle management. The position requires a strategic and hands-on leader with deep expertise in clinical research methodologies, study design, and cross-functional collaboration.

This position reports directly to the Medical Scientific Director. The Associate Scientific Director will work closely with colleagues across Medical Affairs, Clinical Development, Regulatory Affairs, Commercial, as well as external and alliance partners.

Key Responsibilities

• RWE Leadership: Lead the development and execution of RWE generation to address evidence needs in line with Legend Medical Affairs objectives. Formulate research questions, develop study protocols, and design robust methodologies to generate impactful real-world data. A strong collaborative approach with Alliance partners of the Integrated Evidence Team and Real World Value and Evidence teams is required.
• Evidence Generation & Study Oversight: Oversee all data generation activities, including MA led Phase IV studies, RWE studies, Investigator Initiated Studies (IIS), and collaborative research. Manage projects from strategy through execution and dissemination (internal and external).
• Data Gap Analysis & Lifecycle Management: Conduct annual data gap analyses to identify high-value medical affairs-driven studies. Provide leadership in lifecycle evidence management and ensure timely initiation and completion of prioritized studies.
• Budget & Resource Management: Manage project budgets, ensuring efficient resource allocation, vendor management and timely delivery within established financial parameters.
• Cross-Functional Collaboration: Collaborate with internal teams (Clinical Development, Regulatory, Commercial) and external partners to maximize evidence generation and address emerging data needs.
• Project Execution & Tracking: Oversee all aspects of study management, including enrollment, milestone tracking, and reporting progress to stakeholders.
• Represent Legend at relevant internal and external meetings, as well as, congresses, workshops, investigator meetings and other scientific engagements.
• The Associate Scientific Director will typically have the authority to make decisions related to direction, methodologies, approaches in the evidence generation processes. You can also make decisions related to project execution, including timelines, milestones and resource allocation within budget. Higher-level approvals are required for those related to significant budget allocations, strategic shifts, or major collaborations that have substantial financial or long-term implications.

Requirements

• Advanced terminal degree (MD, PharmD, PhD) or other advanced medical degree (NP, PA, etc.) preferred.
• Minimum 5 years of experience in medical affairs and/or clinical research required, with preference for a track record in RWE strategy and evidence generation.
• Understanding of research methodologies, protocol development, data analysis, and interpretation of real-world data. Familiarity with regulatory and compliance requirements in RWE research.
• Demonstrated success in managing complex projects and budgets, and working in cross-functional teams in a matrix environment with a results focused attitude.
• Excellent written and verbal communication skills, with the ability to translate complex scientific concepts into actionable insights for diverse audiences
• Demonstrated proficiency with the most current computer operating systems, Microsoft Office 2013 (particularly Outlook, Word, Excel, and PowerPoint).
• SharePoint, Adobe Acrobat Professional, Concur, Veeva and other PC-based applications. Familiar with AI based platforms including Copilot.
• Understanding of research methodologies, protocol development, data analysis, and interpretation of real-world data. Familiarity with regulatory and compliance requirements in RWE research.
• Demonstrated success in managing complex projects and budgets, and working in cross-functional teams in a matrix environment with a results focused attitude.
• Excellent written and verbal communication skills, with the ability to translate complex scientific concepts into actionable insights for diverse audiences

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Benefits:

We are committed to creating a workplace where employees can thrive - both professionally and personally. To attract and retain top talent in a highly competitive industry, we offer a best-in-class benefits package that supports well-being, financial stability, and long-term career growth. Our offerings are designed to meet the diverse needs of our team members and their families, ensuring they feel valued and supported every step of the way. Highlights include medical, dental, and vision insurance as well as a 401(k)-retirement plan with company match that vest fully on day one. Equity and stock options are available to employees in eligible roles, we offer eight weeks of paid parental leave after just three months of employment, and a paid time off policy that includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S. national holidays, and 3 floating holidays. Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs - demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

Eeo Statement

Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by applicable law.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. Legend may adjust base salary or other discretionary compensation at any time based on individual, team, performance, or market conditions.

Legend Biotech maintains a drug-free workplace.