Senior Director, US Commercial Strategy

The Role:

This role reports directly to the U.S. General Manager and is a key member of the U.S. leadership team. It leads cross-functional commercial strategy for the U.S. respiratory portfolio and will be a critical representative for the U.S. in global portfolio planning forums. It is responsible for driving integration across commercial functions, shaping and executing portfolio strategy, and supporting launch and sales capabilities. The position leads a small team (1–2 direct reports) and will orchestrate resources across matrix teams from Sales, Access, Trade, and Medical. It requires strong cross-functional leadership, strategic thinking, and a bias for execution.

Here’S What You’Ll Do:

Portfolio Strategy & Cross-Functional Integration

• Serve as the central integrator of portfolio strategy, consolidating short- and medium-term product strategies across sales, pricing, market access, marketing, and medical.
• Develop and maintain integrated commercial scenarios that reflect how the portfolio will be launched and sold across customer segments and channels.
• Operationalize a comprehensive view of the economic offering—spanning value proposition, contracting strategy, and customer-level dynamics—across the portfolio.
• Drive alignment across functions by maintaining the operating mechanism that channels inputs from disparate teams into a cohesive strategic plan.
• Ensure consistency and integration in decision-making across the commercial model, enabling a unified go-to-market approach for the U.S. respiratory portfolio.
• Serves as a standing member of the U.S. Commercial Leadership Team, advising the US GM on integrated strategy, resourcing trade-offs, and portfolio performance metrics.

Strategic Initiatives (Design & Execution)

• Support the implementation of key strategic initiatives, partnering with initiative leads to ensure execution excellence and measurable impact.
• Independently lead select initiatives from concept to launch, including design, resourcing, stakeholder alignment, and execution.
• Interface with customers and field-facing teams to ensure strategic initiatives are grounded in real-world needs and can be effectively deployed in-market.
• Collaborate closely with Sales and Marketing to ensure initiatives are commercially viable and integrated into broader team priorities.
• Manages operating budget and vendor relationships tied to strategic initiative delivery, including external consultants or launch partners as needed.

Launch Framework & Excellence

• Partner with the global team to ensure U.S. readiness within the global launch framework, including tailored approaches for each respiratory product launch.
• Champion launch excellence capabilities for both new launches and annual strain updates, embedding best practices, timelines, and accountability structures.
• Act as a key interface between global and U.S. teams to ensure the seamless translation of launch frameworks into country-level execution plans.
• Continuously evolve the launch “engine” by assessing performance and identifying opportunities for standardization, acceleration, or innovation.
• Co-leads U.S. strategy alignment within global commercial forums, representing the U.S. in global portfolio decisions, launch sequencing, and go-to-market design.

Sales Capability & Operating Model Support

• Support the development and rollout of capabilities critical to the U.S. sales organization, including integrated account planning, business reviews, and performance management routines.
• Help define and reinforce the U.S. commercial cadence and operating model to drive clarity, accountability, and cross-functional coordination.
• Contribute to capability-building efforts through content development, workshop facilitation, and adoption monitoring.
• Act as a thought partner to Sales leadership to continuously evolve and scale the team's tools, processes, and commercial execution muscle.

Here’s What You’ll Need (Basic Qualifications):

• Bachelor’S Degree Required

• Minimum 10 years of experience in commercial strategy, portfolio planning, or launch operations, with a strong track record of delivering cross-functional impact across Sales, Access, Marketing, and Medical Affairs
• Proven experience leading cross-functional initiatives involving sales, marketing, market access, and medical affairs
• Strong analytical and strategic thinking skills with a bias toward execution
• Experience leading initiatives with financial accountability, resource planning, or launch delivery in a matrixed biopharma environment
• Excellent communication and stakeholder management skills, including ability to influence without authority
• Demonstrated experience engaging with executive leadership to shape strategic decisions
• Demonstrated ability to thrive in a fast-paced, matrixed environment
• Deep understanding of U.S. healthcare landscape and go-to-market models
• Experience managing direct reports and cross-functional teams
• Proven leadership in global-local coordination for launch or portfolio strategy
• Ownership of commercial initiatives with defined budget, vendor, or P&L accountability
• Here’s What You’ll Bring to the Table (Preferred Qualifications):
• Excellent communication and stakeholder management skills, including ability to influence without authority
• Demonstrated experience engaging with executive leadership to shape strategic decisions
• Demonstrated ability to thrive in a fast-paced, matrixed environment
• Deep understanding of U.S. healthcare landscape and go-to-market models
• Experience managing direct reports and cross-functional teams
• Proven leadership in global-local coordination for launch or portfolio strategy
• Ownership of commercial initiatives with defined budget, vendor, or P&L accountability
• Here’s What You’ll Bring to the Table (Preferred Qualifications):
• MBA or advanced degree preferred
• Prior experience in vaccines, respiratory, or specialty care therapeutic areas
• Familiarity with global/local launch frameworks and U.S. commercialization models
• Comfort operating without direct team or budget ownership, with ability to drive results through others
• Track record of building operating models, planning tools, or sales enablement capabilities
• Experience interfacing with executive leadership and synthesizing input across functions
• Ability to influence resource allocation and strategic decisions at a senior leadership level

At Moderna, we believe that when you feel your best, you can do your best work.  That’s why our US benefits and global well-being resources are designed to support you—at work, at home, and everywhere in between.

• Best-in-class healthcare coverage, plus a suite of voluntary benefit programs to support your unique needs
• A holistic approach to well-being, with access to fitness, mindfulness, and mental health support
• Lifestyle Spending Accounts to personalize your well-being journey
• Family planning and adoption benefits
• Generous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown
• Savings and investment opportunities
• Location-specific perks and extras

About Moderna

Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world.  

By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities. 

We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S. 

If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities. 

Our Working Model

As we build our company, we have always believed an in-person culture is critical to our success. Moderna champions the significant benefits of in-office collaboration by embracing a 70/30 work model. This 70% in-office structure helps to foster a culture rich in innovation, teamwork, and direct mentorship. Join us in shaping a world where every interaction is an opportunity to learn, contribute, and make a meaningful impact. 

Moderna is a smoke-free, alcohol-free, and drug-free work environment. 

Equal Opportunities

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law.  Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!

Moderna is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements. 

Accommodations

We’re focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best. 

Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should contact the Accommodations team at leavesandaccommodations@modernatx.com. 

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