Vice President, Disease Area Franchise Head, Clinical Development

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

As Franchise Head, reporting to the VP, Head of Clinical Development, you will lead and oversee multiple clinical science teams responsible for developing global clinical development plans and ensuring effective and efficient execution for multiple molecules within the assigned disease-area indication. You will guide strategy, priorities, and interpretation of clinical study results. You will interact at high levels internally (e.g., the Development Leadership Team, DRG chairs) and externally (health authorities, key opinion leaders), serving as both a consultant/advisor to RevMed committees and as a public face for the therapeutic area. You will provide guidance to Development Project Team Leads for the development programs under your leadership and shape disease-area’s late-stage portfolio strategy, ensuring alignment between R&D, regulatory, and commercial goals.

Key Responsibilities:

• Lead and own the global clinical development strategy and roadmap for the disease area (lung / colon / pancreas cancer), spanning preclinical through late-phase development, regulatory interactions, and support for eventual commercialization.
• Oversee execution of multiple molecule programs within the disease area: ensure high quality protocol design, site selection, patient recruitment, data integrity, regulatory compliance, and risk/benefit evaluation.
• Serve as clinical & scientific thought leader in the disease area: monitor external science, competitive intelligence, emerging modalities, biomarkers; integrate translational science into clinical programs.
• Act as a primary interface with regulatory authorities, KOLs, external experts/ advisory boards (domestic & international), for clinical strategy, plan negotiation, and feedback.
• Partner closely with cross-functional organizations including Research, Regulatory Affairs, Translational Medicine, Medical Affairs, Commercial, Operations, and Finance to ensure alignment of scientific, regulatory, and commercial objectives.
• Mentor, develop, recruit, and retain talent in your teams; provide leadership to direct reports and non-direct report team members. Ensure training, career development, and performance management.
• Manages direct reports and is accountable for hiring, training, developing, and retaining talent on his/her staff. Ensures consistent compliance with all governing employment laws, regulations, and RevMed HR policies and procedures. Demonstrates strong people leadership through delegating effectively, empowering teams, and ensuring accountability for high-quality outcomes. Prior people-management experience is required, with a proven ability to motivate, coach, and lead both direct and indirect team members toward successful program delivery.
• Establish and maintain processes, tools, systems needed to scale clinical development in the disease area: improve efficiency, quality, regulatory compliance.
• Oversee budgets, resources, timelines, and milestone achievement for disease-area programs. Prioritize between projects; make trade-off decisions as needed.
• Serve on and provide input to internal RevMed governance / committee structures (e.g., DevLT, DRG, protocol review committees).
• Represent RevMed externally: present disease area and molecule development plans, clinical data, and strategy to regulatory agencies, at conferences, in publications.
• Ensure adherence to GCP, ICH, FDA/EMA (and other relevant health authority) guidelines, quality assurance, safety monitoring, benefit-risk assessment.
• Define and drive the disease-area clinical vision; integrating translational science, regulatory pathways, and commercial readiness.
• Lead enterprise portfolio prioritization and investment trade-off decisions through collaboration with R&D, Commercial, and Finance.

Required Skills, Experience & Education:

• MD, PhD or equivalent advanced biomedical degree with 15+ years experience in pharmaceutical / biotech industry (including clinical development in oncology / solid tumors); academic faculty experience outside of industry considered pending transferability of skills and responsibilities.
• Extensive oncology clinical development experience, with deep expertise in solid tumors and a demonstrated ability to rapidly build and apply disease-area knowledge (e.g., lung, colon, pancreas) to guide program strategy and execution.
• Experience authoring and leading clinical development strategies, including label-enabling outcomes, regulatory submissions (e.g., NDA/BLA/MAA) in global settings.
• Strong scientific credibility: publications in peer-reviewed journals, external recognition (KOLs, conferences).
• Proven ability to lead large, cross-functional teams, including both direct and indirect reports; proven ability to mentor, motivate, retain high caliber clinical scientists.
• Demonstrated ability to manage clinical budgets, timelines, resources; strong decision-making in trade-off situations balancing safety, efficacy, speed, cost.
• Excellent communication, presentation, interpersonal skills; ability to influence and collaborate with senior management, external stakeholders, regulatory agencies.
• Experience influencing corporate strategy and external industry direction, including partnerships, senior level interactions, or health authority representation.
• Organizational scaling experience, including leading through growth, change, and commercialization.

Preferred Skills:

• Experience with biomarker-driven trial design, precision medicine, translational science relevant to cancer.
• Prior experience building or refining processes, systems, tools for scaling clinical development in a disease area.
• Experience with commercialization lifecycle, post-approval studies / life-cycle management.
• Experience interacting with health authorities globally across multiple regions.
• Experience in M&A / in-licensing or partnering for external assets relevant to disease-area.
• Successful experience presenting external scientific strategy, communicating to external advisory boards, investigator meetings.
• Oversee multiple Clinical Science teams and Project Team Leads for the disease area. Interacts with cross-functional leads in Translational, Regulatory, and Medical Affairs (amongst others) as matrix.
• Frequent interaction with DevLT (Development Leadership Team), DRG (Development Research Group) Chairs, Regulatory Affairs, Finance, Commercial, Research & Translational Medicine. #LI-Hybrid  #LI-GL1

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Base Pay Salary Range$284,000—$355,000 USD