Vice President, Translational Medicine

Janux Therapeutics is seeking a scientifically rigorous and strategically minded Vice President of Translational Medicine to lead the integration of clinical data across early development programs. This is a hands-on leadership role that requires deep expertise in synthesizing diverse datasets, including PK, PD, biomarkers, safety, efficacy, immunogenicity (ADA), and durability, into a coherent, actionable framework that informs clinical strategy and decision-making.
This leader will not only guide the translational vision but also actively engage in the data, working closely with internal and external teams to ensure that every insight contributes to a clear, logical narrative that supports dose selection, trial design, and regulatory success.

Essential Functions And Responsibilities

• Strategic Integration & Decision Support
• Lead the hands-on integration of clinical data across modalities and endpoints to inform program strategy.
• Develop and communicate a data-driven narrative that connects mechanistic understanding with clinical outcomes.
• Translate complex datasets into clear recommendations for dose selection, trial design, and go/no-go decisions.
• Ensure translational insights are embedded in clinical protocols, regulatory filings, and development milestones.

CrossFunctional Leadership

• Partner with medical leads, clinical science, clinical operations, biomarker, regulatory, and safety teams to align translational strategy with program goals.
• Serve as a key contributor to governance and program teams, representing translational science in strategic discussions.
• Collaborate with external experts and CROs to support modeling, PK analysis, and specialized translational efforts.
• Team Building & Mentorship
• Lead and mentor a growing translational team, fostering a culture of scientific excellence and strategic thinking.
• Define and evolve the function’s capabilities, including biomarker strategy, clinical pharmacology, and data integration.
• Identify and manage external partnerships to complement internal expertise.
• Regulatory & Scientific Engagement
• Support regulatory interactions by providing integrated translational insights and data interpretation.
• Represent the company in scientific forums, advisory boards, and external collaborations.

Required Education, Experience, Skills, And Abilities

• PhD, PharmD, or MD in pharmacology, immunology, translational science, or a related field.
• 12+ years of experience in translational medicine, clinical development, or related areas in biotech/pharma.
• Demonstrated ability to integrate and interpret complex clinical datasets into strategic program decisions from early clinical development to late-stage clinical trials.
• Strong understanding of PK/PD principles, biomarker development, and regulatory expectations.
• Experience with biologics, ADCs, or immunotherapies is highly desirable. Direct experience within oncology and autoimmune will be given priority.
• Exceptional communication skills, with the ability to translate science into strategy and influence cross-functional teams.
• Strong track record of contributing to regulatory submissions and engaging with global health authorities.
• Strong organizational and time management abilities.
• High level of accountability, adaptability, and attention to detail.
• Ability to work independently and collaboratively in a fast-paced, matrixed environment.
• Ability to travel up to 15%

Job Type: Full-time Benefits:·         401K·         Medical insurance·         Dental insurance·         Vision insurance·         Supplemental disability insurance plans·         Flexible schedule·         Life insurance·         Flexible vacation·         Sick time·         Incentive stock option plan·         Relocation assistance Schedule:·         Monday to Friday Work authorization:·         United States (Required) Additional Compensation:·         Annual targeted bonus % Work Location:·         On site (San Diego, CA) EQUAL OPPORTUNITY EMPLOYER:Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.

Notice to Recruiters and Third-Party AgenciesThe Talent Acquisition team manages the recruitment and employment process for Janux. To protect the interests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.