Research Scientist, In vivo pharmacology - 12 month fixed-term contract

Company Description

Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (formerly BT8009), a Bicycle® Drug Conjugate (BDC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BDC molecule targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radioconjugates (BRC®) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, Massachusetts, USA. For more information, visit bicycletherapeutics.com

Job Description

Job Summary

Bicycle Therapeutics is seeking a talented scientist with strong background in in vivo pharmacology and tumor biology to support the preclinical research and discovery efforts for our expanding portfolio of Bicycle -based therapeutics. The successful candidate will have a passion for developing transformational treatment paradigms for cancer patients and will enjoy working across programs and will report to the Associate Director of In vivo Pharmacology.

Key Responsibilities

• Manage in vivo pharmacology research through a network of CROs and academic collaborations
• Design and interpret in vivo pharmacology studies to evaluate the activities of Bicycle® Toxin Conjugates (BTC®), Bicycle® Radio Conjugates (BRC™) and other compounds in our pipeline, including their mechanism of action and PK/PD/efficacy -relationships
• Effectively document and communicate study results
• Effectively collaborate with cross functional disciplines (biology, DMPK, translational sciences, toxicology) and engage internal stake holders to drive decisions

This has a hybrid-working arrangement, with a flexibility on the number of days being onsite.

Qualifications

Key Skills and Competencies

• Relevant experience in the industry setting required
• Hands-on experience using animal disease models (particularly oncology models) required
• Experience in outsourcing in vivo studies is preferred (from contracting to reporting)
• A strong background in cancer biology is preferred
• Experience in working with toxin- or radionuclide-conjugates (antibody or other) is preferred
• Capability of working both independently and as part of multi-disciplinary teams
• Attention to detail and strong interpersonal, organizational and communication skills
• Innovative, entrepreneurial, enjoys working in a fast-paced, small-company environment

Additional Information

• State-of-the-art campus environment
• Competitive reward including annual company bonus
• 28 days annual leave in addition to bank holidays
• Employer contribution to pension (employee does not have to contribute)
• Life assurance cover 4x basic salary
• Private Medical Insurance, including optical and dental cover
• Health Cash Plan
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
• Cycle to work scheme

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.