Director - Oncology Genomics, HGG

Company Overview

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. GSK has kicked off 2025 with impressive growth in sales, profits, and earnings. We anticipate five major new FDA product approvals and 15 phase III/pivotal study readouts over the next two years. So far, we have secured two FDA approvals, with three more expected later this year. By uniting science, technology, and talent, we are committed to getting ahead of disease together. 

Job Purpose

Are you looking for an opportunity to lead a Translational Data Science team within Oncology Genomics in GSK’s Research Technology department and aid in the discovery and development of new cancer medicines? If so, this is the job for you.
 

As a Director in Translational Data Science in the Oncology Genomics team you will lead, plan and coordinate computational biology and genomics projects in partnership with functions across GSK including the Oncology Research Units with the aim to discover and develop the next generation of oncology therapeutics. You will work in an inter-disciplinary environment, frequently interfacing with wet-lab and translational scientists, clinicians, statisticians, and AI/ML colleagues among others.

GSK’s Oncology portfolio has seen significant growth in the past years. In the late-stage setting, we have seen numerous approvals and positive Phase 3 readouts. We also have several early-stage programs aiming to enter the clinic over the years to come.  Oncology is now posed to be a significant growth driver for GSK, allowing us to be ambitious for patients and continue investment into early drug discovery. To achieve these aims requires leadership in computational biology to derive decision making insights from complex oncology genetic and genomic datasets.

Key Responsibilities:

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Lead and build a growing team of Oncology Computational Biologists and Genomicists to support and innovate the Oncology portfolio pipeline
• Contribute scientific expertise and design to multiple drug discovery or development efforts across oncology
• Act as a competent and recognized expert in developing and critiquing the scientific validity of research/development initiatives to drive the development and delivery of long-term scientific strategy in Oncology Genomics
• Individually contribute with analyses and integration of complex cancer datasets. This includes analysis of gene & protein expression (bulk + single cell + spatial), somatic mutations, copy number alterations, and structural variants
• Apply statistical methods and AI/machine learning algorithms to identify patterns in data, predict drug response, and discover potential biomarkers. Critically evaluate results. Conduct survival analysis to assess the impact of various factors on patient outcomes
• Lead the development and use of bioinformatics pipelines
• Serve as a recognized leader in driving technological foresight within specific scientific function or directing content of programs
• Lead and influence the outcome of multidisciplinary meetings including partners in therapeutic research units, translational and clinical development teams.
• Communicate complex scientific findings clearly to both technical and non-technical audiences.
• Maintain current knowledge of advancements in cancer research and computational biology.
• Effectively communicate findings to appropriate senior GSK internal groups
• Utilize your track record of effecting substantial change by applying interdisciplinary knowledge of multiple disciplines and therapeutic areas that impact discovery and/or development in oncology
• Apply scientific skills to influence experimental design and data interpretation that impacts across drug discovery/development
• Define and execute a coordinated and highly influential scientific strategy
• Accountable for decisions affecting major product development activities or business directives and their implementation and for recommending allocation of resources with key matrix partners

Why You?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:
 

• PhD with postdoc or industry experience OR MS with extensive years of related experience in Computational Biology, Bioinformatics, Cancer Biology, or a related field.
• Proven track record of leadership or matrix leadership experience in Computational Biology, Cancer Biology or a related field
• Strong understanding of cancer biology and the drug discovery process.
• Proficiency in Python or R, with experience building bioinformatic workflows and documenting code with version control. 
• Experience working with large-scale oncology datasets (e.g., TCGA, CPTAC, DepMap, PRISM)
• Understanding of statistical methods, machine learning and/or AIML algorithms, and survival analysis techniques.
• If you have the following characteristics, it would be a plus:
• Experience working with large-scale oncology datasets (e.g., TCGA, CPTAC, DepMap, PRISM)
• Understanding of statistical methods, machine learning and/or AIML algorithms, and survival analysis techniques.
• If you have the following characteristics, it would be a plus:

Preferred Qualifications:

• Leadership with line management experience in Data Science in Oncology Research and Development in Industry, Biotech or Academic settings
• Expertise and experience in integrating translational and real-world clinical and ‘omics data with preclinical data for target discovery, biomarker and patient selection strategies
• A strong publication track record and internationally recognized research experience
• Knowledge of multiple disciplines and therapeutic areas that impact discovery/ development policy, processes or guidelines in the pharmaceutical industry
• Demonstrated ability to coordinate outputs from several expertise areas to determine strategy
• Proven track record of effecting substantial change
• Ability to make decisions
• Expert in integration of preclinical development disciplines and commercial strategy into a full-scale product development activity
• Ability to influence others

#Li-Gsk*

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on UKRecruitment.Adjustments@gsk.com or 0808 234 4391.  The helpline is available from 8.30am to 12.00 noon Monday to Friday, during bank holidays these times and days may vary.

Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive .

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/