Principal Software Engineer

Principal Software Engineer

At Refined Sciences

United States (Remote)

At RefinedScience, our mission is to advance care by bringing together the best science, data and minds – disease by disease, patient by patient, cell by cell to discover pathways to life beyond disease.   

What We Are Looking For

We seek a highly skilled and motivated Principal Software Engineer to join our dynamic and growing team. In this role, you will design, implement, and maintain robust cloud-based software tools that enable our scientists, clinicians, and researchers to uncover insights from complex data. You will create innovative tools and platforms that simplify access to cloud resources, reduce complexity, and ensure services are optimized for diverse internal users. This includes identifying common challenges within our cloud environment and developing standardized, scalable solutions that empower teams to focus on their core work.  As the first hire in our end-user Software development team, you will set standards, establish best practices, and contribute to the team's growth. You will collaborate closely with data science, clinical, and informatics teams, providing the infrastructure and tooling they need to accelerate workloads and research efforts. While our primary environment is Google Cloud Platform (GCP), direct experience with GCP is not required.  What matters most is a strong foundation in cloud architecture, software engineering best practices, and the ability to deliver scalable solutions.  Success in this role requires a self-motivated engineer who thrives on reducing complexity and building tools, software, and cloud infrastructure solutions that empower the organization.

Key Activities

• Develop, implement, and maintain customized software tools used for data visualization & analysis by researchers and clinicians.
• Translate prototype tools developed by data scientists and bioinformaticians into robust end-user software and build tools and processes to enable faster software development.
• Lead the development and oversight of our software development capabilities.
• Advocate for and advise other technical team members to implement best practices in software development, including code reusability, modularity, and maintainability.
• Use generative AI tools to increase efficiency of software development and coding within the company.
• Continuously evaluate and adopt new technologies to enhance our software products and align with industry best practices.
• Manage cloud services, including monitoring, backup, and disaster recovery, security, and compliance
• Advocate for the use of containerization technologies such as Docker and Kubernetes within the organization and train team members on best practices for deploying and maintaining containerized workloads
• Support the deployment and maintenance of internal front-end applications, and assist in setting up and configuring load balancers, DNS, SSL, cloud router, NAT, and other related technologies
• Create and maintain technical documentation for cloud-based solutions and processes.
• Implement monitoring and alerting within applications to proactively identify and resolve issues before they impact users.

Must Haves

• Extensive experience in software development with proficiency in one or more programming languages (e.g., C#, React/Native, PHP).
• Strong understanding of cloud architecture and deployment methodologies.
• Strong knowledge and experience with scripting languages (Bash, Python, PS)
• Competent with containerization technologies such as Docker and Kubernetes.
• Strong understanding of software security best practices.
• Experience with asynchronous, event-based architectures.
• Excellent problem-solving and analytical skills.
• Strong written and verbal communication skills.
• Ability to work independently and in a team environment.

Nice To Haves

• Four years of experience with Google Cloud Platform (GCP), Amazon Web Services (AWS) or Azure.
• Experience developing software solutions in regulated industries such as biotechnology, pharmaceuticals, medical devices, clinical research, or similar sectors.
• Experience working with Agile/Scrum methodologies.
• Experience with web development using frameworks and languages like React.js, Node.js, and TypeScript.
• Knowledge of additional front-end frameworks/libraries and their integration with modern web development practices.
• Familiarity with building APIs.
• Experience with front-end application deployment
• Strong understanding of cloud-based networking components, including load balancers, DNS, SSL, Cloud Router, and NAT technologies.
• Experience with infrastructure as code (IaC) tools such as Terraform, CloudFormation, Ansible, and Pulumi.
• Experience creating automation scripts to accomplish infrastructure provisioning, configuration management, or application deployment.
• Experience creating and maintaining dashboards for monitoring cloud infrastructure and application performance using tools like Google Cloud Monitoring, Grafana, or similar platforms.

Why You’Ll Love Refined Science

Team + Values

At RefinedScience, we seamlessly integrate top-tier clinical and biological data with expert knowledge to provide unparalleled insights.  We maximize patient impact with these unique insights by optimizing clinical trial probability of success and time to actionable results. We work across biopharma and we are a trusted partner in achieving better results, faster – working together to unlock strategic advantage.

Our Values

• Act with Purpose – We believe in rigor through deliberate and thoughtful actions
• Be Curious – Curiosity is the spark that ignites innovation and growth
• Take Ownership – True ownership leads to pride and commitment in the work we do
• Invest in Relationships – Building strong connections is the foundation for effective collaboration and trust for long term success
• Embrace Agility – We celebrate agile thinking, resilience, and adaptability

What We Offer

• The target salary range is $160,000 – $200,000
• Base pay offered may vary within the posted range based on several factors, including but not limited to education, job-related knowledge, skills, experience, and location.

Benefits

• Medical, Dental and Vision insurance 
• Life, AD&D, Short-term and Long-term Disability Insurance (none is100% covered)
• HSA Spending Accounts
• 22 Vacation days
• 10 Paid Holidays and Sick Time (120 hours per year)
• 401(K) Plan

At RefinedSciences, we believe diversity drives innovation. In order to commit to health for ALL PEOPLE and create positive impact, we’re building a culture where difference is valued. We take a holistic approach. We’re always growing our network of people, programs and tools all designed to help employees grow and manage their careers.