Head of Program Management

About Us

Dianthus Therapeutics is a publicly traded, clinical-stage biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency. Based in New York City and Waltham, Mass., Dianthus is comprised of an experienced team of biotech and pharma executives who are leading the development of next-generation antibody complement therapeutics, aiming to deliver transformative medicines for people living with severe autoimmune and inflammatory diseases. To learn more, please visit www.dianthustx.com and follow us on LinkedIn.

About The Role

As the Head of Program Management, you will be responsible for establishing and leading a centralized program management function across the organization.

Reporting to the Chief Development and Medical Affairs Officer, you will oversee the planning, execution, and delivery of all R&D and corporate programs, ensuring alignment with strategic goals, timelines, and budgets. The ideal candidate is a seasoned biotech leader with deep experience in program and portfolio management, cross-functional leadership, and organizational integration.

This is an exciting time to join a growing biotech company as we build a pipeline. We are building a culture of individuals who hold our core principles at the center of our operations, with the goal to elevate the care of our patients’ lives. We are open to you working remotely.

Key Responsibilities

• Build and Lead PMO: Design and implement a centralized Program Management Office to support all development programs and corporate initiatives.
• Program Oversight: Provide strategic oversight and hands-on leadership for key programs across discovery, preclinical, clinical, regulatory, and commercial functions.
• Integration & Alignment: Integrate existing program management practices across departments into a unified framework with standardized tools, processes, and governance.
• Portfolio Management: Develop and maintain portfolio dashboards, KPIs, and reporting mechanisms for executive leadership and board-level visibility.
• Cross-Functional Leadership: Partner with R&D, Clinical, Regulatory, Finance, and Operations to ensure program milestones are met and risks are proactively managed.
• Strategic Planning: Support long-range planning and scenario modeling to inform investment decisions and resource allocation.
• Team Development: Recruit, mentor, and develop a high-performing program management team.

Experience

• 15+ years of experience in biotech/pharma, with at least 7 years in program or portfolio management leadership roles.
• Advanced Degree highly preferred (PhD, MBA, or MS in Business or Scientific discipline).
• Proven track record of building and scaling PMO functions in high-growth environments.
• Deep understanding of drug development lifecycle from discovery through commercialization.
• Strong leadership, communication, and stakeholder management skills.
• Experience with project management tools and systems (e.g., Smartsheet, MS Project)