Project Management Senior Manager, CMC Development and Manufacturing (Boston, MA)

Job Description

Vertex Pharmaceuticals is seeking a Senior Manager, Project Management to join the Project Management Office (PMO) within the Biopharmaceutical Sciences Cell and Gene Therapy (CGT) organization. This role is critical in enabling effective, data-driven project execution through the development, implementation, and continuous improvement of project management tools, templates, dashboards, and reporting systems.

The successful candidate will play a key role in enhancing visibility into project scope, timelines, budgets, resources, and risks across the portfolio—enabling more informed and nimble decisions, optimizing project execution, and improving efficiency across multi-disciplinary  teams. With a digital and analytical mindset, the ideal candidate will leverage technology and take a data-centric approach to optimizing project management solutions. This position will report directly to the Senior Director, Head of the Project Management Office.

Key Responsibilities

• Lead the design, development, deployment and continuous improvement of PMO tools and reporting systems to support cross-functional project execution in CGT development and manufacturing.
• Develop and refine standardized processes, templates, and dashboards to improve visibility into project scope, timelines, costs, resource allocation, and risk management.
• Lead the development of dashboards and self-service tools that empower teams to explore, analyze, and act on data.
• Partner with project managers, program leads, and functional leads to drive adoption of new tools and consistent project management approaches across the CGT organization.
• Translate project execution data into actionable insights and forecast projections, supporting timeline optimization and resource planning at both project and portfolio levels.
• Identify and implement integrated, digital and AI-driven tools to increase the efficiency and impact of project management systems.
• Monitor the effectiveness of new tools/processes and lead continuous improvement cycles based on stakeholder feedback and evolving needs.
• Introduce new digital tools to simplify and integrate data across the portfolio and make recommendations for new ways to enhance/optimize existing project management software solutions

Qualifications

• Experience developing and implementing project reporting tools, dashboards, or digital PM systems in a complex, matrixed organization.
• Proficient in project management platforms (e.g., Smartsheet, MS Project, Planisware) and data visualization tools (e.g., Tableau, Power BI).
• Comfort with exploring and integrating digital or AI technologies into project planning and reporting workflows.
• Strong organizational, analytical, and communication skills, with the ability to manage multiple priorities and influence across functional lines.
• Ability to work both strategically and tactically, independently and collaboratively, in a fast-paced, dynamic environment.
• PMP certification or advanced project management training a plus.
• Bachelor’s degree in a scientific or business-related discipline required.
• Minimum of 5 years of project management experience in the pharmaceutical, biotech, or biologics industry.
• Demonstrated understanding of CMC development and manufacturing processes preferred.

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Pay Range:

$146,600 - $219,900

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.  From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

• In this Hybrid-Eligible role, you can choose to be designated as: 
• 1.    Hybrid: work remotely up to two days per week; or select
• 2.    On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. 
 

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com