Director/Sr. Director, Capital Markets Finance

We are seeking a dynamic Capital Markets team member, preferably with a background in investment banking or equity research, to build, and execute, a best-in-class capital markets strategy. This role will be the primary liaison to analysts and investors, while also serving as a trusted advisor to senior leadership on how Wall Street views our strategy, pipeline, and financial performance. 
The successful candidate thrives at the intersection of finance, science, and storytelling, translating complex clinical and operational data into compelling investor-ready narratives that resonate with institutional investors and analysts. 

Primary Responsibilities

• In partnership with Lexeo leadership, build a world-class capital markets program, overseeing all messaging, external communications, and investor engagement strategy 
• Partner with the CEO, CFO, and senior leadership on quarterly earnings, roadshows, analyst days, and capital markets initiatives 
• Coordinate preparation of investor-facing materials: earning scripts, Q&A prep, press releases and corporate presentations 
• Serve as a spokesperson for the company with institutional investors and analysts
• Monitor sell-side coverage, investor sentiment, peer activity, and sector dynamics to anticipate market reactions 
• Build and maintain sophisticated financial models, comps, and valuation scenarios to inform both investor messaging and internal decision-making 
• Provide leadership with insights into market opportunities, risks, and investor priorities. 
• Prepare and/or deliver investor-informed readouts of clinical, operational, and R&D data to executives and the Board. 
• Advise internal teams on framing pipeline milestones, trial timelines, and value drivers for Wall Street. 
• Partner with leadership to refine pipeline and corporate strategy through the lens of investor expectations. 
• Coordinate quarterly earnings process end-to-end, including script, deck, Q&A prep, and messaging 
• Manage investor conferences, non-deal roadshows, analyst days, and targeted outreach programs 
• Ensure all external communications comply with SEC and regulatory requirements 
• Conduct benchmarking of peers’ pipelines, valuation frameworks, and investor narratives. 
• Translate insights into actionable recommendations for internal strategy and external messaging 

Required Skills & Qualifications

• Bachelor’s degree in finance, economics, business, or life sciences required; MBA or CFA strongly preferred. Medical or scientific background a plus.  
• 7-10 years in capital markets, investor relations, equity research, investment banking, or corporate strategy 
• Biotech/pharma experience preferred; must demonstrate ability to interpret and communicate complex clinical data 
• Proven track record of direct engagement with institutional investors, analysts and capital markets stakeholders  
• Strong financial modeling, valuation, and market analysis expertise 
• Exceptional communication and executive presence, with ability to influence both internal leaders and external stakeholders 

About Lexeo
LEXEO Therapeutics is a New York City-based, clinical-stage gene therapy company focused on addressing some of the most devastating genetically defined cardiovascular and central nervous system diseases affecting both larger-rare and prevalent patient populations. LEXEO’s foundational science stems from partnerships and exclusive licenses with leading academic laboratories at Weill Cornell Medicine and the University of California, San Diego. LEXEO is advancing a deep and diverse pipeline of AAV-based gene therapy candidates in rare cardiovascular diseases and APOE4-associated Alzheimer’s disease and is led by pioneers and experts with decades of collective experience in genetic medicines, rare disease drug development, manufacturing, and commercialization
Our work culture is a hybrid model with 2 days/week in the New York City office and days working from home.  Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.