Postdoctoral Research Associate

A postdoctoral fellowship in medicinal chemistry is available in the laboratory of Dr. Richard Lee to perform structure-based drug design and synthesis of drug candidates as part of an interdisciplinary research team.

A postdoctoral fellowship in medicinal chemistry is available in the laboratory of Dr. Richard Lee to perform structure-based drug design and synthesis of drug candidates as part of an interdisciplinary research team.  The ideal candidate will have a strong background in medicinal chemistry and chemical biology.  The candidate will be responsible for the design and synthesis of lead optimization series using emerging structure-activity relationships that consider both target and drug metabolism factors.  Experience in antibiotic chemistry, CNS drug discovery, computer-aided drug design, ADME and PK profiling, LC-MS, and NMR analysis would be advantageous.  The successful candidate must be an effective communicator and team player, keep an accurate notebook, and maintain a safe working environment.

Postdoctoral trainees in the Department of Chemical Biology and Therapeutics have access to outstanding facilities for inhibitor discovery, including access to large chemical screening libraries; analytical chemistry and ADME support; high-throughput and biophysical screening capabilities; and high-resolution structural biology, including crystallography, NMR spectroscopy, and cryo-electron microscopy.  Each fellow has access to a dedicated fume hood and rotavap, electronic notebook, Biotage flash chromatography system, NMR, and UPLC-MS.

Eligibility: A recent PhD. in medicinal chemistry, chemical biology, or organic chemistry is required. The successful applicant will be a good communicator in oral and written English with a track record of publication in top chemistry journals and a proven record of chemical synthesis.

St. Jude is an Equal Opportunity Employer

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