High-Throughput Biology Screening Co-op

Orna Therapeutics, Inc. is a Watertown-based biotechnology startup on a mission to create therapies for diseases inaccessible to existing approaches. Built on novel circular RNA technology developed at MIT, Orna is leading the next wave of RNA therapeutics with our best-in-class expression and delivery platform.

We are seeking a motivated and detail-oriented Co-op Student to join our team and support high-throughput gene editing screening projects. The successful candidate will gain hands-on experience with cell culture, gene editing, next-generation sequencing (NGS), and automation technologies that drive large-scale biological discovery. This role is ideal for students interested in molecular biology, biotechnology, or biomedical sciences who are looking to apply their academic knowledge in a dynamic research environment.

Key Responsibilities

• Cell Culture Support
• High-Throughput Screening
• NGS Sample Preparation
• General Laboratory Support
•  Support primary and/or immortalized mammalian cell culture activities under sterile conditions.
• Perform routine cell culture techniques including plating, passaging, counting and transfection.
• Monitor cell growth, viability, and morphology.
• Assist in the setup and execution of large-scale biological assays.
• Operate and maintain laboratory automation and liquid handling systems.
• Collect, record, and analyze experimental data following established protocols.
• Perform automated and manual NGS library preparation and execute sequencing workflows.
• Conduct quality checks on sequencing libraries and resulting data to ensure accuracy and integrity.
• Work closely with team members to troubleshoot and optimize protocols.
• Prepare reagents, buffers, and media as needed.
• Maintain accurate lab notebooks and electronic records.
• Follow safety guidelines and maintain a clean, organized workspace.

Qualifications

• Graduate or undergraduate student currently enrolled in Biology, Biotechnology, Molecular Biology, Biomedical Sciences, or a related field.
• Basic knowledge of cell culture techniques and molecular biology methods is desirable.
• Familiarity with next-generation sequencing workflows is an asset but not required.
• Strong attention to detail, organizational skills, and ability to follow standard operating procedures.
• Willingness to learn and work in a collaborative, fast-paced environment.

Learning Opportunities

• Gain practical training in mammalian cell culture and high-throughput biological screening.
• Acquire hands-on experience with cutting-edge NGS workflows and automation technologies.
• Learn to manage experimental workflows, analyze data, and contribute to discovery efforts.
• Work alongside experienced scientists and be mentored in both technical and professional skills.

Why work at Orna?

In addition to working alongside bright and hardworking colleagues, you’ll have the opportunity to experience an array of benefits throughout your time with us, including: 

• Invitations to company outings and social events
• Opportunities to meet with our Executive and Management teams
• Participation in department specific and organization wide meetings and trainings
• Various personal and professional development opportunities
• Transportation or parking expenses
• Company swag
• Coverage under MA Sick Time and MA Paid Family and Medical Leave
• Paid holidays, except company shutdowns, and two days of vacation, eligible after a 90-day probationary period

Equal Employment Opportunity Statement

Individuals seeking employment at Orna Therapeutics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation. 

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