Postdoctoral Research Associate - Surgery

The Yang Lab in Department of Surgery at St. Jude Children’s Research Hospital is seeking a highly motivated Postdoctoral Fellow to join our translational research team.

The research focuses on understanding and targeting epigenetic and splicing factors in high-risk neuroblastoma. This work is highly mechanistic and translational, leveraging cutting-edge genetic, epigenomic, and pharmacologic tools in patient-derived xenografts and genetically engineered mouse models to inform better therapies.

Key Responsibilities

• Design and conduct experiments investigating the role of epigenetic regulators in regulating therapy resistance.

• Utilize molecular, cellular, and biochemical techniques including CRISPR, RNA-seq, CUT&RUN, ATAC-seq, HiC, flow cytometry, and 3D tumor modeling.

• Analyze how epigenetic modulation alters chromatin states and cell state transitions.

• Evaluate preclinical efficacy of molecular glue drugs in combination with standard therapies.

• Collaborate within a multidisciplinary team including cancer biologists and clinicians.

• Present findings at national and international meetings and contribute to manuscript preparation and grant proposals.

Qualifications

• A Ph.D. (or nearing completion) in molecular biology, cancer biology, biochemistry, developmental biology, immunology, or related fields.

• Strong background in epigenetics, transcriptional regulation, or chromatin biology is highly desirable.

• Experience with mouse models, genome editing, or next-generation sequencing is a plus.

• Excellent communication skills, critical thinking, and a collaborative mindset.

• A strong publication record demonstrating scientific rigor and productivity.

St. Jude is an Equal Opportunity Employer

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