Postdoctoral Fellow, Inflammation & Immunology

Postdoctoral Fellow, Inflammation and Fibrosis
 

Use Your Power for Purpose

At Pfizer, our purpose is to deliver breakthroughs that transform patients' lives. Central to this mission is our Research and Development team, which strives to convert advanced science and cutting-edge technologies into impactful therapies and vaccines. Whether you are engaged in discovery sciences, ensuring drug safety and efficacy, or supporting clinical trials, your role is crucial. You will leverage innovative design and process development capabilities to expedite the delivery of top-tier medicines to patients globally.

What You Will Achieve

The Myeloid Cell and Tissue Repair group within the Inflammation and Immunology Research Unit at Cambridge, MA is seeking a highly motivated Ph.D.-level scientist to join our Discovery group as a Postdoctoral Research Fellow. This role will advance therapeutic innovation through the exploration of macrophage biology in inflammation and fibrotic disease pathophysiology.
 

The postdoctoral research project aims to investigate the functional and molecular identity of efferocytic macrophages in injury, inflammation, and fibrosis. This includes determining how apoptotic cargo and environmental cues shape macrophage phagocytic behavior and evaluating approaches to redirect efferocytosis for therapeutic benefit. The project will integrate state-of-the-art techniques including multiplex analysis, imaging, flow cytometry, omics profiling, and gene-editing technologies. 

The ideal candidate should have solid training in immunology and cell biology with computational proficiency. The Postdoctoral Fellow will gain expertise in myeloid cell biology, work collaboratively across Pfizer’s multidisciplinary teams, and contribute to high-impact publications. By the end of the program, the postdoctoral fellow will be skilled in experimental design, complex data analysis, and effective science communication. 

In this role, you will:

• Conduct research and development activities to support the discovery of new therapies.

• Contribute intellectually and at the bench to the design and analysis of studies.

• Independently interpret and analyze data to communicate findings to mentor, making decisions using technical knowledge under supervision.

• Develop and apply complex in vitro assays, including macrophage functional assays and co-culture assays.

• Run multiparametric assays including high content imaging with immunofluorescence, high parameter flow cytometry, multiplex biochemical assays and transcriptomics.

• Present research work at internal and external meetings and publish in high-impact journals.

• Ensure all tasks and responsibilities are carried out according to scientific and ethical standards.

• Build team skills and a culture of scientific excellence and continuous learning.
   

Here Is What You Need (Minimum Requirements):

• A Ph.D. in immunology or cell biology.

• No more than 2 years of post-degree experience.

• At least 1 first-author scientific research article publication in high-quality specialty or general readership journals.

• Demonstrated experience in diverse molecular and biochemical laboratory techniques applied to in vitro cell characterization at molecular and genetic levels (fixed/live cell imaging, ELISA and flow cytometry, transcriptome/RNA-seq).

• Knowledge and application of computational analysis and coding pipelines (e.g., R Studio, Python).

• Excellent communication and writing skills.

• Well organized, self-motivated, team oriented, ability to multitask with attention to detail.

• Ability to work collaboratively in a team environment.

• Willingness to make a minimum 2-year commitment.
   

Bonus Points If You Have (Preferred Requirements):

• Experience in complex culture/co-culture systems of human primary cells, including immune (myeloid) cell isolation and iPSC culture.

• Experience in in vitro gene editing approaches.

• Proficiency in omic data analysis software and tools.

• In-depth, hands-on knowledge of myeloid/stromal inflammation and fibrosis.

  

PHYSICAL/MENTAL REQUIREMENTS

Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis.

Relocation support available

Work Location Assignment: Hybrid

The annual base salary for this position ranges from $62,700.00 to $104,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.  These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.  Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.  Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.  If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.  This position requires permanent work authorization in the United States.

Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.

Research and Development