Senior Scientist

 

Work Your Magic with us! Start your next chapter and join MilliporeSigma.

 

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.  

 

Your Role: 

As a Senior Bioinformatician in MilliporeSigma’s Next Generation Sequencing (NGS) R&D group at our Rockville, Maryland site, you will drive innovation in genomic research by developing advanced computational tools and analytical pipelines. Your work will bridge computational biology and molecular biology, enabling breakthroughs in transgenic evaluation, CRISPR-based studies, biosafety assessments, and other genomic applications. Leveraging your expertise in NGS, bioinformatics, genomics, and computer science, you will lead efforts to automate and optimize data analysis workflows, ensure software quality, and deliver actionable insights from complex genomic datasets.

• Pipeline Development & Automation: Design, build, and enhance modular workflows and applications using Python, R, and Unix shell scripting for NGS data analysis. Implement these solutions in cloud-based platforms and local server environments to support scalable, high-throughput genomic services. Continuously test and refine existing tools to improve robustness and efficiency.
• Genomic Data Management: Develop and maintain database systems to organize large-scale genomic data. Create scripts to standardize data formats, ensuring seamless integration with analytical pipelines and downstream applications.
• Advanced Data Analysis & Interpretation: Analyze NGS datasets from multiple platforms (e.g., Illumina, Oxford Nanopore) and applications (e.g., WGS, RNA-seq, CRISPR screens) to extract biological insights. Integrate results with project objectives, identify trends across short- and long-read sequencing data, and provide data-driven recommendations to guide experimental design.
• Visualization & Reporting: Design and develop interactive visualization modules and pipelines using tools like Python (e.g., matplotlib, seaborn), R (e.g., ggplot2, circosplot), or platforms like Tableau to transform complex NGS data into intuitive, actionable insights. Conduct multi-dimensional analysis to explore diverse data perspectives (e.g., statistical trends, biological patterns, technical artifacts) and identify optimal visualization strategies for varied audiences. This includes tailoring color schemes, plot granularity (e.g., font size, tick density, axis labels, legends), and interactivity levels to balance detail with clarity. Collaborate with team to iteratively refine visual outputs, ensuring accessibility and interpretability while maintaining scientific accuracy.
• Troubleshooting & Problem-Solving: Diagnose and resolve issues in data analysis, algorithm design, and infrastructure (e.g., software, OS, network). Propose innovative solutions to technical challenges in pipeline development or data interpretation.
• Quality Assurance & Documentation: Ensure the reliability of software and analytical outputs through rigorous validation. Maintain detailed records of code, workflows, and analyses to uphold reproducibility and compliance with scientific standards.

Who You Are

Minimum Qualifications:
•    Master's Degree of Bioinformatics, Computational Biology, Genomic Biology, and Computer Sciences with 4+ years of experience in academia or industry’s R&D
•    Demonstrated evidence in BFX tool and pipeline development

 Preferred Qualifications:
•    Doctorate Degree of Bioinformatics, Computational Biology, Genomic Biology, and Computer Sciences with 2+ years of academic and/or biotechnology R&D experience
•    Organizational and Time Management Skills: Excellent time management skills with the ability to work under minimal supervision; Strong organizational skills, including the capacity to efficiently evaluate, prioritize, and manage multiple dynamic projects and priorities.
•    Documentation Skills: Ability to draft standard operating procedures, technical documents, assay and workflow design documentation, software lifecycle documentation, system risk assessments, user requirement specifications, and related documentation; Experience in performing peer reviews of related documentation and processes, with the ability to interpret and summarize scientific results clearly, concisely, and accurately.
•    Computational Skills: Proficiency in coding languages such as Python, R, Bash, and JavaScript; Experience with high-performance computing servers; proficiency in data manipulation using dataframes (e.g., Pandas/Polars) and databases (e.g., SQL/NoSQL, knowledge graph databases); Experience with workflow management tools such as NextFlow, CWL on-prem and on cloud based BFX platforms.
•    Genomic Visualization: Experience with genomic data visualization tools like IGV and UCSC Genome Browser; Experience with genome assembly; Familiarity with Ensembl and Gencode annotation; Experience with reannotation; General data visualization skills, including scatter plots, circos plots, and density plots; Web development expertise with a focus on interactive data visualization.
•    Cloud and Containerization: Experience with cloud platforms like Amazon Web Services (AWS) or Google Cloud Platform (GCP); Proficiency in using Docker environments; Version Control: Experience with version control systems such as GitHub or Bitbucket.

 

Pay Range: $117,400- $192,400

 

Our ranges incorporate all levels and career types available within this specific role, and are derived from relevant industry market data.  Should we decide to make an offer, we will consider several factors, including but not limited to your location, skills, experience, career level, and other job-related factors.  This role may offer the following benefits: medical, vision, and dental insurance; life insurance; disability insurance; a 401(k) matching program; paid time off; and paid holidays; among other employee benefits. This role may also be eligible for short-term or long-term incentive compensation, including, but not limited to, cash bonuses. 

 

What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!

 

Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!