Associate Director, Clinical Pharmacology

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are seeking a passionate and experienced Clinical Pharmacologist with strong early development background to be part of the Nonclinical Development and Clinical Pharmacology (NDCP) Organization. 

As a member of the Early Development Clinical Pharmacology group, you will:

• Work as a member of the Clinical Study Team (CST).

• Provide strong Clinical Pharmacology support as well as author technical reports and/or regulatory documents for major milestones of clinical development, specifically IND, EOP1 & EOP2 Briefing Documents.

• Represent Clin Pharm at Regulatory Agency meetings such as EOP1 or EPO2 meetings if needed.

• Work effortlessly with the Discovery organization to support assets in the IND-enabling stage, including collaboration with DMPK and Toxicology groups in assessment of human start dose and assessment of the need for human DDI studies.

• Work with the Clinical Development team and CST in covering Clin Pharm activities such as design of dose-escalation (Phase 1A) study.

• Work with the Clinical Development team and CST in covering Clin Pharm activities such as design of dose-expansion/optimization (Phase 1B) study.

• Work on design and reporting of Clin Pharm studies such as hADME, Food-Effect and DDI studies.

• Provide guidance to the Clin Pharm Operations teams in assessment of NCA work.

• Work with Clinical Operations team in identifying CROs for execution of Clin Pharm studies.

Required Skills, Experience and Education:

• A Ph.D. or Pharm.D (with Fellowship) with Pharmaceutical Sciences background with 6+ years of relevant industry experience in Clinical Pharmacology.

• Well-informed in current and emerging standards of regulatory requirements and expectations for pharmacometrics and clinical pharmacology.

• Solid knowledge and hands-on experience in Clin Pharm study designs.

• Strong understanding of DMPK, CMC and Toxicology and related regulatory guidance is required.

• Excellent verbal and written communication skills, and ability to clearly convey complex concepts and findings to both non-specialist and specialist audiences.

• A critical thinker and passionate team player and quick learner with high energy who thrives in a dynamic and fast-paced environment.

Preferred Skills:

• Prior experience with small molecules in the oncology therapeutic area.

The base salary range for this full-time position is $180,000 to $225,000 for candidates working onsite at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the salary for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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