At Lyterian Therapeutics, we are committed to developing medicines for patients in need by co-opting physiologically-relevant protein homeostatic mechanisms to regulate genetically-validated targets. As Principal Scientist, Medicinal Chemistry, you will leverage your extensive experience in and passion for the discovery and optimization of small molecule therapeutics to advance Lyterian’s internal pipeline toward the clinic. You will work closely with the senior management team and be directly responsible for leading and growing Lyterian’s internal and external teams of chemists. We look for teammates who are inspired by our mission and want to work in a collaborative, rigorous, and entrepreneurial environment. We seek candidates who are self-motivated, collaborative, proactive, and possess a strong desire to discover novel biology and new drugs. Efficient time management, excellent organizational and communication skills, and passion for high-quality, translational science are essential.

Impact You'll Make:

Design and develop small molecule compounds, libraries, and probes based on rigorous data analysis and sound hypotheses
Collaborate and supervise the synthesis of designed small molecules, libraries, and probes at CROs
Develop and contribute to company's intellectual property (IP) domain by way of patents and/or publications
Stay up-to-date with emerging scientific literature
Collaborate and communicate across a diverse scientific team to successfully progress Lyterian goals

Qualifications:

PhD in chemistry with 7-10 years relevant industry experience, at least 3 years in a Drug Discovery setting
Expertise in small molecule chemistry (structure-based and/or pharmacophore-based drug design, synthetic organic chemistry, ADME/DMPK optimization)
Record of accomplishment in one or more of the following areas: medicinal chemistry, methodology/catalysis, total synthesis, and optionally chemical biology and physical organic chemistry
Track record of advancing small molecule medicinal chemistry programs leading to clinical candidates is preferred
Experience with compound scale-up and is a plus
Understanding and utilization of computer-aided drug design (CADD)
Initiative and boldness to dive into a fast-paced new startup

At Lyterian, we believe that a diverse, open, and inclusive environment and culture is key to our success. We will not be influenced in recruiting, hiring, promoting or any other employment practices by race, color, citizenship status, national origin, ancestry, sex, sexual orientation, gender identity/expression, age, religion, physical or mental disability, medical or genetic condition, marital status, veteran status, or any other characteristics protected under applicable federal, state and local laws. Lyterian will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable laws. Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation.