The Oligo Platform Biology Investigator/Science Leader will help establish and manage a sequencing team within GSK’s oligo platform biology lab. Areas of focus are: establishing RNA sequencing for on and off target evaluation of oligos, as well as amplicon sequencing and long read seq. The candidate will build a team to support both project screening and exploratory biology efforts and serve as the sequencing expert for the team. Oligo modalities for evaluation include ASO, siRNA, SSO and RNA editing oligos.

Key Responsibilities

• Establish NGS/RNA sequencing capabilities for oligos from the ground up, including team hire/build, instrument and assay set up and validation and associated workflows

• Identify and develop robust and reproducible sequencing assays to support portfolio and platform projects including RNA sequencing for on and off target evaluation (short and long read) and amplicon seq at 96/384 well scale

• Recruit, manage and develop a small team of scientists (1-3) to enable successful delivery of project and platform goals

• Oversee the design, execution and troubleshooting of experiments including the analysis and presentation of data across groups

• Continually optimize and validate new biological assays to drive identification and characterization of superior oligonucleotide therapeutics at GSK

Serve as the sequencing subject matter expert for Oligo Biology in various cross functional meetings

Why You?

Basic Qualifications:

• PhD with 8+ years, MS with 10+ in molecular or cell biology or related field 4+ years of industry experience NGS – RNA seq focus
• Expertise with various NGS assays including RNA seq (short and long read), amplicon seq
• Experience in RNA biology, assay development and troubleshooting
• 2+ years of supervisory/management experience

Preferred Qualifications:

• Demonstrated expertise with various NGS assays including RNA sequencing and Amplicon sequencing. Experience with Nanostring, long-read seq and ddPCR is a plus
• Experience with therapeutic oligonucleotides (ASO, siRNA, SSO’s, RNA Editors) is desired
• Demonstrated expertise in RNA biology, assay development and troubleshooting
• At least 3 years of supervisory/management experience
• Experience with high throughput liquid handlers is a plus
• Independent individual with strong initiative

#LI-GSK

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Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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